+44 (0)1509 263171
Please use this identifier to cite or link to this item:
|Title: ||Towards the development of a polymorphic control approach in sulfathiazole crystalization|
|Authors: ||Abu Bakar, Mohd R.|
Nagy, Zoltan K.
Rielly, Chris D.
|Issue Date: ||2008|
|Publisher: ||© Shaker Publishing|
|Citation: ||ABU BAKAR, M.R., NAGY, Z.K. and RIELLY, C.D., 2008. Towards the development of a polymorphic control approach in sulfathiazole crystalization. IN: Lorenz, H. and Kaemmerer, H. (eds.). BIWIC 2008 / 15th International Workshop on Industrial Crystallization, September 10-12, 2008, Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg, Germany. Aachen : Shaker Publishing, pp. 235-242|
|Abstract: ||Controlling the formation of a specific polymorphic form of active pharmaceutical ingredients,
particularly those that exhibit multiple polymorphic forms, during crystallization is critical for
pharmaceutical manufacturers. This paper describes the construction of a phase diagram using
Lasentec Focused Beam Reflectance Measurement (FBRM), which is an important step in the
development of an approach for polymorphic control of sulfathiazole, an antimicrobial agent that
is known to crystallize as a mixture of polymorphs. A preliminary work on mapping of different
regions in the phase diagram, where various polymorphic forms were found, is also reported
here. This study is part of a larger study on polymorphic control of pharmaceuticals through
supersaturation control using Process Analytical Technology.|
|Description: ||This conference paper was published in BIWIC 2008 [© Shaker Publishing] which is available from: http://www.shaker.eu/|
|Version: ||Accepted for publication|
|Appears in Collections:||Conference Papers and Presentations (Chemical Engineering)|
Files associated with this item:
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.