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Title: Towards the development of a polymorphic control approach in sulfathiazole crystalization
Authors: Abu Bakar, Mohd R.
Nagy, Zoltan K.
Rielly, Chris D.
Issue Date: 2008
Publisher: © Shaker Publishing
Citation: ABU BAKAR, M.R., NAGY, Z.K. and RIELLY, C.D., 2008. Towards the development of a polymorphic control approach in sulfathiazole crystalization. IN: Lorenz, H. and Kaemmerer, H. (eds.). BIWIC 2008 / 15th International Workshop on Industrial Crystallization, September 10-12, 2008, Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg, Germany. Aachen : Shaker Publishing, pp. 235-242
Abstract: Controlling the formation of a specific polymorphic form of active pharmaceutical ingredients, particularly those that exhibit multiple polymorphic forms, during crystallization is critical for pharmaceutical manufacturers. This paper describes the construction of a phase diagram using Lasentec Focused Beam Reflectance Measurement (FBRM), which is an important step in the development of an approach for polymorphic control of sulfathiazole, an antimicrobial agent that is known to crystallize as a mixture of polymorphs. A preliminary work on mapping of different regions in the phase diagram, where various polymorphic forms were found, is also reported here. This study is part of a larger study on polymorphic control of pharmaceuticals through supersaturation control using Process Analytical Technology.
Description: This conference paper was published in BIWIC 2008 [© Shaker Publishing] which is available from: http://www.shaker.eu/
Version: Accepted for publication
URI: https://dspace.lboro.ac.uk/2134/4750
ISBN: 9783832275051
Appears in Collections:Conference Papers and Presentations (Chemical Engineering)

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