Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/4957

Title: Simulation based optimization of microneedle geometry to improve drug permeability in skin
Authors: Olatunji, Ololade
Das, Diganta Bhusan
Al-Qallaf, Barrak
Issue Date: 2009
Publisher: © Eurosis
Citation: OLATUNJI, O., DAS, D.B. and AL-QALLAF, B., 2009. Simulation based optimization of microneedle geometry to improve drug permeability in skin. IN: Proceedings of the 7th Industrial Simulation Conference' 2009 (ISC'2009), Loughborough, UK, pp. 293-300
Abstract: Microneedles are a method of transdermal drug delivery which overcomes the barrier of the stratum corneum by piercing through with little or no pain. Microneedle have been shown to increase the skin permeability but the extent to which they do so is affected by the design of the microneedles due to certain parameters such as tip radius, base radius, pitch, number of microneedles on the patch and penetration depth. In this study a framework is developed to optimize these parameters and an optimum geometry for a microneedle shape is proposed. Simulations using two different softwares where then carried out to analyze the effect of these parameters on the diffusive flux and concentration of the drug in the blood. We found that the results of the numerical optimization and the results from the computer simulations led to the same conclusion about the optimum dimensions for the chosen geometry.
Description: This is a conference paper. It is also available at: http://www.eurosis.org/cms/?q=node/905
Version: Accepted for publication
URI: https://dspace.lboro.ac.uk/2134/4957
ISBN: 9789077381489
Appears in Collections:Conference Papers and Presentations (Chemical Engineering)

Files associated with this item:

File Description SizeFormat
Olatunji_etal_ISC09.pdf237.71 kBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.