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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/4989

Title: Adaptive concentration control of cooling and antisolvent crystallization with laser backscattering measurement
Authors: Woo, Xing Yi
Nagy, Zoltan K.
Tan, Reginald B. H.
Braatz, Richard D.
Issue Date: 2009
Publisher: © American Chemical Society
Citation: WOO, X.Y. ... et al, 2009. Adaptive concentration control of cooling and antisolvent crystallization with laser backscattering measurement. Crystal Growth and Design, 9 (1), pp. 182-191
Abstract: The paper presents a thorough simulation and experimental evaluation of the concentration control approach for batch and semibatch crystallization. The sensitivity of concentration feedback control is assessed in the case of various disturbances that result in excessive nucleation events. The enhanced robustness of the concentration control is demonstrated against the widely used direct operation approach, which directly implements the temperature or anti-solvent addition rate versus time. Two adaptive supersaturation control approaches are proposed that employ measurement of the number of particle counts per unit time provided by in-situ laser backscattering, to detect the onset of nucleation and adapt the operating curve accordingly, further enhancing the robustness of the approach. Simulation and experimental results indicate that adaptive concentration control is robust to variations in the nucleation, growth, or dissolution rates due to scale-up or other changes in the process conditions.
Description: This article is Restricted Access. It was published in the journal, Crystal Growth and Design [© American Chemical Society] and is available from: http://pubs.acs.org/doi/abs/10.1021/cg800131r
Version: Restricted access
DOI: 10.1021/cg800131r
URI: https://dspace.lboro.ac.uk/2134/4989
ISSN: 1528-7483
Appears in Collections:Closed Access (Chemical Engineering)

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