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|Title: ||Adaptive concentration control of cooling and antisolvent crystallization with laser backscattering measurement|
|Authors: ||Woo, Xing Yi|
Nagy, Zoltan K.
Tan, Reginald B. H.
Braatz, Richard D.
|Issue Date: ||2009|
|Publisher: ||© American Chemical Society|
|Citation: ||WOO, X.Y. ... et al, 2009. Adaptive concentration control of cooling and antisolvent crystallization with laser backscattering measurement. Crystal Growth and Design, 9 (1), pp. 182-191|
|Abstract: ||The paper presents a thorough simulation and experimental evaluation of the concentration control
approach for batch and semibatch crystallization. The sensitivity of concentration feedback control is
assessed in the case of various disturbances that result in excessive nucleation events. The enhanced
robustness of the concentration control is demonstrated against the widely used direct operation approach,
which directly implements the temperature or anti-solvent addition rate versus time. Two adaptive
supersaturation control approaches are proposed that employ measurement of the number of particle counts
per unit time provided by in-situ laser backscattering, to detect the onset of nucleation and adapt the
operating curve accordingly, further enhancing the robustness of the approach. Simulation and
experimental results indicate that adaptive concentration control is robust to variations in the nucleation,
growth, or dissolution rates due to scale-up or other changes in the process conditions.|
|Description: ||This article is Restricted Access. It was published in the journal, Crystal Growth and Design [© American Chemical Society] and is available from: http://pubs.acs.org/doi/abs/10.1021/cg800131r|
|Version: ||Restricted access|
|Appears in Collections:||Closed Access (Chemical Engineering)|
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