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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/4993

Title: Modelling and control of combined cooling and antisolvent crystallization processes
Authors: Nagy, Zoltan K.
Fujiwara, M.
Braatz, Richard D.
Keywords: Crystallization control
Optimal control
Process analytical technology
Issue Date: 2008
Publisher: © Elsevier
Citation: NAGY, Z.K., FUJIWARA, M. and BRAATZ, R.D., 2008. Modelling and control of combined cooling and antisolvent crystallization processes. Journal of Process Control, 18 (9), pp. 856-864.
Abstract: Although for decades nearly all pharmaceuticals have been purified by crystallization, there have been a disproportionate number of problems associated with the operation and control of these processes. This paper provides an overview of the recent advances in model-based and model-free (direct design) approaches to control the crystallization of pharmaceuticals, treating both antisolvent and cooling crystallization. A model-based combined technique which simultaneously controls the antisolvent addition rate and the cooling profile is presented. A population balance model of the combined cooling-antisolvent addition system is developed and a moments model is used in optimal control strategies with various objective functions. The simulation and experimental results show the advantages of the combined approach.
Description: This article was published in the Journal of Process Control [© Elsevier]. The definitive version is available at: www.elsevier.com/locate/jprocont
Version: Accepted for publication
DOI: 10.1016/j.jprocont.2008.06.002
URI: https://dspace.lboro.ac.uk/2134/4993
ISSN: 0959-1524
Appears in Collections:Published Articles (Chemical Engineering)

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