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|Title: ||PLGA particle production for water soluble drug encapsulation: degradation and release behaviour|
|Authors: ||Gasparini, G.|
|Keywords: ||Membrane emulsification|
|Issue Date: ||2010|
|Publisher: ||© Elsevier|
|Citation: ||GASPARINI, G., HOLDICH, R.G. and KOSVINTSEV, S.R., 2010. PLGA particle production for water soluble drug encapsulation: degradation and release behaviour. Colloids and Surfaces B: Biointerfaces, 75 (2), pp. 557-564.|
|Abstract: ||Particles for subcutaneous depot use encapsulating a model water soluble
drug have been produced from poly(lactic-glycolic acid) (PLGA) using a
membrane emulsification – solvent evaporation technique. The release
behaviour, mainly the change in size and inner morphology are reported.
During release, the particles initially swelled in size, then reduced. A diffusion
based model, taking in to account the change in particle size, is presented.
Surface erosion is evident from the particle size and image evidence, and the
diffusion model provides a fit to the data even during the surface erosion
period, suggesting that the model drug diffuses before the particle degrades.|
|Description: ||This is a journal article. It was published in the journal, Colloids and Surfaces B: Biointerfaces [© Elsevier] and the definitive version is available at: www.elsevier.com/locate/colsurfb|
|Version: ||Accepted for publication|
|Appears in Collections:||Published Articles (Chemical Engineering)|
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