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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/5651

Title: PLGA particle production for water soluble drug encapsulation: degradation and release behaviour
Authors: Gasparini, G.
Holdich, R.G.
Kosvintsev, S.R.
Keywords: Membrane emulsification
Diffusion
Surface erosion
Issue Date: 2010
Publisher: © Elsevier
Citation: GASPARINI, G., HOLDICH, R.G. and KOSVINTSEV, S.R., 2010. PLGA particle production for water soluble drug encapsulation: degradation and release behaviour. Colloids and Surfaces B: Biointerfaces, 75 (2), pp. 557-564.
Abstract: Particles for subcutaneous depot use encapsulating a model water soluble drug have been produced from poly(lactic-glycolic acid) (PLGA) using a membrane emulsification – solvent evaporation technique. The release behaviour, mainly the change in size and inner morphology are reported. During release, the particles initially swelled in size, then reduced. A diffusion based model, taking in to account the change in particle size, is presented. Surface erosion is evident from the particle size and image evidence, and the diffusion model provides a fit to the data even during the surface erosion period, suggesting that the model drug diffuses before the particle degrades.
Description: This is a journal article. It was published in the journal, Colloids and Surfaces B: Biointerfaces [© Elsevier] and the definitive version is available at: www.elsevier.com/locate/colsurfb
Version: Accepted for publication
DOI: 10.1016/j.colsurfb.2009.09.035
URI: https://dspace.lboro.ac.uk/2134/5651
ISSN: 0927-7765
Appears in Collections:Published Articles (Chemical Engineering)

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