4_SiNa09_CES_repository.pdf (2.3 MB)
Comparison of external bulk video imaging with focused beam reflectance measurement and ultra-violet visible spectroscopy for metastable zone identification in food and pharmaceutical crystallization processes
journal contribution
posted on 2009-12-11, 15:15 authored by Levente L. Simon, Zoltan NagyZoltan Nagy, Konrad HungerbuhlerThe purpose of the paper is twofold: it describes the proof of concept of the newly
introduced bulk video imaging (BVI) method and it presents the comparison with
existing process analytical technologies (PAT) such as focused beam reflectance
measurement (FBRM) and ultra violet/visible (UV/Vis) spectroscopy. While the latter
two sample the system in small volumes closely to the probe, the BVI approach monitors
the entire or large parts of the crystallizer volume. The BVI method is proposed as a
complementary noninvasive PAT tool and it is shown that it is able to detect the
boundaries of the metastable zone with comparable or better performance than the FBRM
and UV/VIS probes.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Citation
SIMON, L.L., NAGY, Z.K. and HUNGERBUHLER, K., 2009. Comparison of external bulk video imaging with focused beam reflectance measurement and ultra violet-visible spectroscopy for metastable zone identification in food and pharmaceutical crystallization processes. Chemical Engineering Science, 64 (14), pp. 3344-3351.Publisher
© ElsevierVersion
- AM (Accepted Manuscript)
Publication date
2009Notes
This is a journal article. It was published in the Chemical Engineering Journal [© Elsevier] and the definitive version is available www.elsevier.com/locate/cesISSN
1385-8947Language
- en