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|Title: ||Endoscopy based in-situ bulk video imaging of batch crystallization processes|
|Authors: ||Simon, Levente L.|
Nagy, Zoltan K.
|Issue Date: ||2009|
|Publisher: ||© ACS Publications|
|Citation: ||SIMON, L.L., NAGY, Z.K. and HUNGERBUHLER, K., 2009. Endoscopy based in-situ bulk video imaging of batch crystallization processes. Organic Process Research and Development, 13 (6), pp.1254-1261.|
|Abstract: ||External bulk video imaging (eBVI) of crystallization processes has proven to be a
promising technique for metastable zone determination. In this contribution the
endoscopy based in-situ bulk video imaging (iBVI) method is introduced. The video data
is processed using the mean gray intensity method and by a digital image processing
technique which aims to detect the first crystals during nucleation. The experiments have
been carried out in a small scale calorimeter CRCv4, during which the compensation
heater and infrared spectroscopy signals were monitored.
It is concluded that monitoring the onset of the apparent nucleation, formation of particles
with detectable size, using the mean gray intensity (MGI) trend delivers similar
performance to the calorimetric and IR spectroscopy signal, whereas the crystal
recognition method is the fastest, allowing to detect nucleation earlier.
The endoscopy based nucleation monitoring technique is proposed as a complementary
tool to existing process analytical technologies (PAT) since it provides an in-situ, lowcost,
robust, probe-based method for metastable zone identification which can be easily
integrated and automated with existing laboratory hardware and software.|
|Description: ||This article is closed access. It was published in the journal, Organic Process Research & Development [© ACS Publications]: http://pubs.acs.org/journal/oprdfk|
|Version: ||Closed access|
|Appears in Collections:||Closed Access (Chemical Engineering)|
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