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Title: Endoscopy based in-situ bulk video imaging of batch crystallization processes
Authors: Simon, Levente L.
Nagy, Zoltan K.
Hungerbuhler, Konrad
Issue Date: 2009
Publisher: © ACS Publications
Citation: SIMON, L.L., NAGY, Z.K. and HUNGERBUHLER, K., 2009. Endoscopy based in-situ bulk video imaging of batch crystallization processes. Organic Process Research and Development, 13 (6), pp.1254-1261.
Abstract: External bulk video imaging (eBVI) of crystallization processes has proven to be a promising technique for metastable zone determination. In this contribution the endoscopy based in-situ bulk video imaging (iBVI) method is introduced. The video data is processed using the mean gray intensity method and by a digital image processing technique which aims to detect the first crystals during nucleation. The experiments have been carried out in a small scale calorimeter CRCv4, during which the compensation heater and infrared spectroscopy signals were monitored. It is concluded that monitoring the onset of the apparent nucleation, formation of particles with detectable size, using the mean gray intensity (MGI) trend delivers similar performance to the calorimetric and IR spectroscopy signal, whereas the crystal recognition method is the fastest, allowing to detect nucleation earlier. The endoscopy based nucleation monitoring technique is proposed as a complementary tool to existing process analytical technologies (PAT) since it provides an in-situ, lowcost, robust, probe-based method for metastable zone identification which can be easily integrated and automated with existing laboratory hardware and software.
Description: This article is closed access. It was published in the journal, Organic Process Research & Development [© ACS Publications]: http://pubs.acs.org/journal/oprdfk
Version: Closed access
DOI: 10.1021/op900019b
URI: https://dspace.lboro.ac.uk/2134/5680
ISSN: 1083-6160
1520-586X
Appears in Collections:Closed Access (Chemical Engineering)

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