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|Title: ||Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material|
|Authors: ||Cottam, Emily|
Hukins, David W.L.
Hewitt, Christopher J.
Jenkins, Mike J.
|Keywords: ||Cell proliferation|
|Issue Date: ||2009|
|Publisher: ||© Elsevier|
|Citation: ||COTTAM, E. ... et al, 2009. Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material. Medical Engineering & Physics, 31 (2), pp. 221-226.|
|Abstract: ||Polycaprolactone (PCL) is a promising potential material for tissue engineering
scaffolds. This paper investigates the effect of sterilisation by gamma irradiation (dose
2.5 Mrad) on degradation rate (catalysed by lipase), mechanical properties and the
ability of cells to attach and subsequently grow on its surface. Gel permeation
chromatography (GPC) was used to determine the effects of gamma irradiation of
weight average, Mw, and number average, Mn, molecular weights. Gamma irradiation
significantly decreased the rate of degradation, although the rates depended on the
initial mass of polymer. It also significantly altered the mechanical properties,
increasing the yield stress. PCL failed in tension by three different mechanisms.
Irradiation significantly increased the failure stress, when the failure mechanisms
were considered separately but not when they were combined. It caused a significant
increase in Mw and decrease in Mn that could be attributed to chain scission and crosslinking.
Chondrocyte attachment and growth on PCL was not significantly affected by
|Description: ||This article was published in the journal Medical Engineering & Physics [© Elsevier] and the definitive version is available at@: http://www.elsevier.com/wps/locate/medengphy|
|Version: ||Accepted for publication|
|Appears in Collections:||Published Articles (Chemical Engineering)|
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