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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/5762

Title: Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material
Authors: Cottam, Emily
Hukins, David W.L.
Lee, Kenneth
Hewitt, Christopher J.
Jenkins, Mike J.
Keywords: Cell proliferation
Mechanical properties
Issue Date: 2009
Publisher: © Elsevier
Citation: COTTAM, E. ... et al, 2009. Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material. Medical Engineering & Physics, 31 (2), pp. 221-226.
Abstract: Polycaprolactone (PCL) is a promising potential material for tissue engineering scaffolds. This paper investigates the effect of sterilisation by gamma irradiation (dose 2.5 Mrad) on degradation rate (catalysed by lipase), mechanical properties and the ability of cells to attach and subsequently grow on its surface. Gel permeation chromatography (GPC) was used to determine the effects of gamma irradiation of weight average, Mw, and number average, Mn, molecular weights. Gamma irradiation significantly decreased the rate of degradation, although the rates depended on the initial mass of polymer. It also significantly altered the mechanical properties, increasing the yield stress. PCL failed in tension by three different mechanisms. Irradiation significantly increased the failure stress, when the failure mechanisms were considered separately but not when they were combined. It caused a significant increase in Mw and decrease in Mn that could be attributed to chain scission and crosslinking. Chondrocyte attachment and growth on PCL was not significantly affected by gamma irradiation.
Description: This article was published in the journal Medical Engineering & Physics [© Elsevier] and the definitive version is available at@: http://www.elsevier.com/wps/locate/medengphy
Version: Accepted for publication
DOI: 10.1016/j.medengphy.2008.07.005
URI: https://dspace.lboro.ac.uk/2134/5762
ISSN: 1350-4533
Appears in Collections:Published Articles (Chemical Engineering)

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