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Title: Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma
Authors: Lee, H.J.
Shon, C.H.
Kim, Y.S.
Kim, S.
Kim, G.C.
Kong, Michael G.
Issue Date: 2009
Publisher: © IOP Publishing Ltd and Deutsche Physikalische Gesellschaft
Citation: LEE, H.J....et al., 2009. Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma. New Journal of Physics, 11(115026), 13pp.
Abstract: Increased expression of integrins and focal adhesion kinase (FAK) is important for the survival, growth and metastasis of melanoma cells. Based on this well-established observation in oncology, we propose to use degradation of integrin and FAK proteins as a potential strategy for melanoma cancer therapy. A low-temperature radio-frequency atmospheric microplasma jet is used to study their effects on the adhesion molecules of G361 melanoma cells. Microplasma treatment is shown to (1) cause significant cell detachment from the bottom of microtiter plates coated with collagen, (2) induce the death of human melanoma cells, (3) inhibit the expression of integrin 2, integrin 4 and FAK on the cell surface and finally (4) change well-stretched actin filaments to a diffuse pattern. These results suggest that cold atmospheric pressure plasmas can strongly inhibit the adhesion of melanoma cells by reducing the activities of adhesion proteins such as integrins and FAK, key biomolecules that are known to be important in malignant transformation and acquisition of metastatic phenotypes.
Description: This article was published in the journal, New Journal of Physics, [© IOP Publishing Ltd and Deutsche Physikalische Gesellschaft] and is also available at: http://dx.doi.org/10.1088/1367-2630/11/11/115026
Version: Published
DOI: 10.1088/1367-2630/11/11/115026
URI: https://dspace.lboro.ac.uk/2134/6308
ISSN: 1367-2630
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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