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Title: Multiscale information modelling for heart morphogenesis
Authors: Abdulla, Tariq
Imms, Ryan
Schleich, Jean-Marc
Summers, Ron
Issue Date: 2010
Publisher: © Tariq Abdulla/ Ryan Imms/ Jean-Marc Schleich/ Ron Summers
Citation: ABDULLA, T. ... et al., 2010. Multiscale information modelling for heart morphogenesis. Journal of Physics: Conference Series, 238 (1), 012062 [Paper presented at:13th IMEKO TC1-TC7 Joint Symposium, 1-3 September 2010, City University London, UK.]
Abstract: Science is made feasible by the adoption of common systems of units. As research has become more data intensive, especially in the biomedical domain, it requires the adoption of a common system of information models, to make explicit the relationship between one set of data and another, regardless of format. This is being realised through the OBO Foundry to develop a suite of reference ontologies, and NCBO Bioportal to provide services to integrate biomedical resources and functionality to visualise and create mappings between ontology terms. Biomedical experts tend to be focused at one level of spatial scale, be it biochemistry, cell biology, or anatomy. Likewise, the ontologies they use tend to be focused at a particular level of scale. There is increasing interest in a multiscale systems approach, which attempts to integrate between different levels of scale to gain understanding of emergent effects. This is a return to physiological medicine with a computational emphasis, exemplified by the worldwide Physiome initiative, and the European Union funded Network of Excellence in the Virtual Physiological Human. However, little work has been done on how information modelling itself may be tailored to a multiscale systems approach. We demonstrate how this can be done for the complex process of heart morphogenesis, which requires multiscale understanding in both time and spatial domains. Such an effort enables the integration of multiscale metrology.
Description: This is a conference paper. Details of the conference can be found at: http://imeko.iopconfs.org/index.html
Version: Published
DOI: 10.1088/1742-6596/238/1/012062
URI: https://dspace.lboro.ac.uk/2134/6665
Publisher Link: http://dx.doi.org/10.1088/1742-6596/238/1/012062
ISSN: 1742-6588
Appears in Collections:Conference Papers and Presentations (Mechanical, Electrical and Manufacturing Engineering)

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