Pharmaceuticailn novation is a complex task that is reliant upon the availability of
relevant information and knowledge. To date, the aspects of how, when and where
this information and knowledge is applied throughout the drug development
processes, has been lightly researched. Furthermore, the science of Knowledge
Management can potentially aid the drug development processes and allow an
organisation to reduce the time and costs associated with innovative drug development. This thesis examines these issues in greater depth through a series of case studies conducted within the innovative pharmaceutical organisation AstraZeneca. The end result of this research is a Knowledge Management tool set which is capable of driving pharmaceutical innovation. The thesis firstly explores the literature associated with innovation, pharmaceutical
innovation, Knowledge Management and Intellectual Capital. The second aspect of
the research used the literature review to develop a novel research framework with
which to examine pharmaceutical innovation in greater detail. The third stage of the
research utilised the results of the previous stages to develop a novel Innovation and Knowledge Management focused model. The fourth stage of this research utilised the research findings to develop a Knowledge Management tool set that can be used to drive innovation. This tool set is comprised of three distinct levels of functionality, namely: the social and collaborative level, the information assimilation and dissemination level and a level that encourages the capture of knowledge. The final stage of the research concludes with a discussion on evaluating Knowledge Management and its use in driving pharmaceutical innovation.
Doctoral Thesis. Submitted in partial fulfillment of the requirements for the award of Doctor of Philosophy of Loughborough University.