Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/9113

Title: The application of intramolecular n-acyliminium cyclisation strategies towards biologically active heterocycles
Authors: Towler, Joannah M.R.
Issue Date: 2011
Publisher: © Joannah M.R. Towler
Abstract: We describe the application of N-acyliminium cyclisation strategies to access a range of heterocycles with potential for biological activity. We have described an asymmetric approach towards the anti-tumour pyrroloisoquinoline alkaloid (R)-(+)-crispine A. We have achieved a synthesis of the pyrrolo[2,1-a]benzazepine template which is a sub-unit of the Homoerythrina alkaloids, and the functionalised dodecahydrobenz[a]indolo[3,2-h]quinolizine template, which is a sub-unit of the manadomanzamine alkaloids. In addition, we have described an asymmetric synthesis of the α-hydrazino pyrroloisoquinoline ring system, towards the synthesis of conformationally restricted peptidomimetics.
Description: A dissertation thesis submitted in partial fulfilment of the requirements for the award of the Engineering Doctorate (EngD) degree, at Loughborough University.
URI: https://dspace.lboro.ac.uk/2134/9113
ISBN: 9781907382543
Appears in Collections:EngD Theses (CICE)

Files associated with this item:

File Description SizeFormat
Form-2011-Towler.pdf1.21 MBAdobe PDFView/Open
Thesis-2011-Towler.pdf6.24 MBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.