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Title: | The application of intramolecular n-acyliminium cyclisation strategies towards biologically active heterocycles |
Authors: | Towler, Joannah M.R. |
Issue Date: | 2011 |
Publisher: | © Joannah M. R. Towler |
Abstract: | We describe the application of N-acyliminium cyclisation strategies to access a range of heterocycles with potential for biological activity. We have described an asymmetric approach towards the anti-tumour pyrroloisoquinoline alkaloid (R)-(+)-crispine A. We have achieved a synthesis of the pyrrolo[2,1-a]benzazepine template which is a sub-unit of the Homoerythrina alkaloids, and the functionalised dodecahydrobenz[a]indolo[3,2-h]quinolizine template, which is a sub-unit of the manadomanzamine alkaloids. In addition, we have described an asymmetric synthesis of the α-hydrazino pyrroloisoquinoline ring system, towards the synthesis of conformationally restricted peptidomimetics. |
Description: | A dissertation thesis submitted in partial fulfilment of the requirements for the award of the Engineering Doctorate (EngD) degree, at Loughborough University. |
URI: | https://dspace.lboro.ac.uk/2134/9113 |
ISBN: | 9781907382543 |
Appears in Collections: | Published Theses (CICE)
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